Autonomic Nervous System in Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Autonomic nervous system involvement in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a chronic pulmonary vascular disease characterized by increased pulmonary vascular resistance (PVR) leading to right ventricular (RV) failure. Autonomic nervous system involvement in the pathogenesis of PAH has been demonstrated several years ago, however the extent of this involvement is not fully understood. PAH is associated with increased sympathetic...
متن کاملClinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension
P ulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome defined by an isolated increase in pulmonary vascular resistance (PVR) and eventual right ventricular failure [1]. In spite of progress achieved during the last two decades, the condition remains severe, with a median survival limited to 5–6 yrs and persistent functional limitation in approximately half of the survivors ...
متن کاملClinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension.
In their editorial, R. Naeije and P. van de Borne discuss the cause of exercise hyperventilation in PAH, as well as in patients with congestive heart failure, and attribute it mainly to an increased chemosensitivity on the basis of some previous inert gases studies. In fact, three factors determine the ventilatory response to exercise, 1) the CO2 production, 2) the ratio of physiological dead s...
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An increased sympathetic drive combined with decreased parasympathetic inhibition is found in patients with borderline hypertension, who characteristically have rapid heart rates, high cardiac output and relatively normal vascular resistance (hyperkinetic state). In established hypertension, cardiac output is normal, vascular resistance is elevated and signs of increased sympathetic drive are a...
متن کاملThe Autonomic Nervous System and Hypertension
That hypertension is due to a derangement of sympathetic and parasympathetic cardiovascular regulation is one of the most widely accredited and tested hypotheses in cardiovascular research. Its proposal followed from the demonstration that autonomic cardiovascular influences play a fundamental role in homeostatic control of the cardiovascular system. In animal models of hypertension, both an in...
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ژورنال
عنوان ژورنال: Circulation
سال: 2018
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.117.032355